Health Condition 1: L638- Other alopecia areata
Conditions
Interventions
Intervention1: Tofacitinib with Microneedling: Topical 2 percent Tofacitinib ointment, one fingertip unit to be applied twice daily topically over alopecia patch for 24 weeks and combined with microne
Sponsors
Dr Rohit Singh Chauhan
Eligibility
Inclusion criteria
Inclusion criteria: Patients between the age group of 18 to 50 yrs Diagnosed with alopecia aerate exhibiting at least two patches of alopecia involving the scalp No history of treatment with microneedling or within 1 month before enrollment in study Willingness to adhere to the study protocol and attend follow-up visits
Exclusion criteria
Exclusion criteria: Active scalp infections or skin diseases systemic immunosuppressive or steroid therapy Known hypersensitivity to tofacitinib or any other study components Prior hair transplantation Any coagulation disorder or thrombocytopenia Patients having alopecia totalis and universalis history of cancer or hepatitis B or C, tuberculin test or IGRA test and HIV virus positive patients pregnant women and children more than 18 years of deranged biochemical profile
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage improvement in the Severity of the alopecia tool score in both groupsTimepoint: 0, 24 weeks, 48 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Trichoscopic findings ( terminal hairs, white dots, black dots, exclaimation mark sign)Timepoint: 0, 6th, 12th month;2. Global photographic assessment at baseline, 6th month and 12th month and comparision between themTimepoint: o, 6th, 12th month;3. Hair pull test and assessment at baseline, 6th month and 12th month and comparision between themTimepoint: 0, 6th, 12th month | — |
Countries
India
Contacts
Public ContactDr Sunil Kumar Gupta
All India Institute of Medical Sciences, Gorakhpuur
Outcome results
None listed