Postoperative Pain following Endodontic Treatment using reduced graphene oxide silver nanoparticles Solution

Comparative evaluation of post operative pain following single visit endodontic treatment using graphene oxide silver nano particle irrigant Vs conventional root canal irrigants - Randomized clinical trail - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/082357

Enrollment

200

Registered

2025-03-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: 5% reduced graphene oxide with silver nano particles solution: Dose: 5% graphene oxide silver nanoparticle irrigant Frequency: Single-use during root canal treatment Route of Administr

Eligibility

Inclusion criteria

Inclusion criteria: Age between 18 and 65 years. Single/multi-rooted teeth requiring single-visit endodontic treatment. Teeth with or without periapical lesions. Absence of alterations causing a significant increase in preparation time.

Exclusion criteria

Exclusion criteria: Presence of pain in more than one tooth in the same quadrant. Teeth with open apices. Presence of systemic diseases. Antibiotic use within 1 week prior to the study. Missing opposing teeth or cracked teeth. Pregnant patients.

Design outcomes

Primary

Measure	Time frame
Incidence and intensity of postoperative pain will be assessed.Timepoint: 24hr, 48hr, 72 hr and 1 week	—

Secondary

Measure	Time frame
evaluate additional factors such as pain medication usage, treatment time, irrigation volume, and any adverse eventsTimepoint: 24 hr, 48 hr, 72 and 1 week	—

Countries

India

Contacts

Public ContactGeeth deepika

Professor

anand.sherwood@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026