comparison of diltiazem gel therapy and surgical intervention in treatment of chronic fissure in ano

A comparative study of topical 2 percent of Diltiazem gel versus lateral internal sphincterotomy in the treatment chronic fissure in Ano in a tertiary care centre in Nagpur a randomized control trial - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/082324

Enrollment

Registered

2025-03-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K601- Chronic anal fissure

Interventions

Intervention1: 2 percent diltiazem gel: One group will be intervened by 2 percent diltiazem gel Patient will be advised to apply the gel into the anus at least one and half cm. before and after defec

Eligibility

Inclusion criteria

Inclusion criteria: Clinically diagnosed as case of Chronic Fissure in Ano Patients between 18 to 60 years of age of either gender

Exclusion criteria

Exclusion criteria: Childrens and mentally handicapped patients. Recurrent fissures. Fissures along with hemorrhoids or /and fistula Fissures associated with malignancies ,other comorbidities condition like diabetes mellitus, hypertension etc . Fissures secondary to specific diseases like tuberculosis, Crohn’s disease ,PLHIV, etc

Design outcomes

Primary

Measure	Time frame
Pain relief will be assessed using Visual Analogue Scale on post intervention 1, 4 and 6 weekTimepoint: 1, 4 and 6 week	—

Secondary

Measure	Time frame
Change in Anal tone pressure will be assessed by Sphinctometer on 1,4,and 6 weeksTimepoint: 1, 4 and 6 weeks	—

Countries

India

Contacts

Public ContactDr Tippanna Talwar

All India Institute of Medical Sciences Nagpur

tippannatalawar50@gmail.com9513025029

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026