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To compare the effect of tab clonidine with tab pregabalin for decreasing of stress response to laryngoscopy and intubation in patients posted for elective general anaesthesia

Comparision of oral clonidine with oral pregabalin in attenuation of the pressor response to direct laryngoscopy and tracheal intubation - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/082299
Enrollment
80
Registered
2025-03-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: - Health Condition 3: H661- Chronic tubotympanic suppurative otitis media

Interventions

Intervention1: two drugs, oral clonidine 200 mcg and oral pregabalin used prior to laryngoscopy and intubation: two drugs, oral clonidine 200 mcg and oral pregabalin used prior to laryngoscopy and int

Sponsors

Darshini Shashidharan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: all ASA grade 1 and 2 patients between 18 to 65 years age group.

Exclusion criteria

Exclusion criteria: 1)ASA grade 3 and 4 2) patients with diabetes and hypertension 3) patients who have drug allergy 4) pregnant and lactating women 5) patients with chronic respiratory and cardiovascular disease

Design outcomes

Primary

MeasureTime frame
to study and compare the effects of oral clonidine 200 mcg with oral pregabalin 150 mg on hemodynamic response to laryngoscopy and endotracheal intubationTimepoint: From shifting on ot table till 15 mins post endotracheal intubation

Secondary

MeasureTime frame
1) to evaluate any side effects with use of this drugs. 2)seadtion and anxiety scoresTimepoint: 90 mins prior intubation to 15 mins after intubation

Countries

India

Contacts

Public ContactDR Sudarshan M B

Mysore Medical College and Research Institute

drmbs1975@yahoo.com9900262710

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026