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Investigating the Efficacy of Low Dose Steroids in Reducing Postoperative Pain and Improving Sleep Quality Following Primary Total Knee Arthroplasty: A Randomized Controlled Trial

Investigating the Efficacy of Low Dose Steroids in Reducing Postoperative Pain and Improving Sleep Quality Following Primary Total Knee Arthroplasty: A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/082281
Enrollment
100
Registered
2025-03-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee

Interventions

Intervention1: Tablet Deflazocort: The intervention group receive low-dose steroids (Deflazacort 6mg orally) once daily for 3 weeks postoperatively Control Intervention1: Vitamin B complex tablet: The

Sponsors

Ganga hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: adult patients aged 45-80 years with a diagnosis of advanced knee osteoarthritis requiring total knee arthroplasty

Exclusion criteria

Exclusion criteria: Exclusion criteria will include patients with rheumatoid arthritis, contraindications to steroid use, history of chronic steroid therapy, and significant comorbidities impacting pain perception and sleep quality.

Design outcomes

Primary

MeasureTime frame
1) To assess the effectiveness of low-dose steroids in reducing postoperative pain and local warmth following primary TKA. 2) To evaluate the impact of low-dose steroids on sleep quality in the postoperative period after primary TKA.Timepoint: At baseline preoperatively, postoperative day 3, 1 month, 3 months and 6 months postoperatively.—

Secondary

MeasureTime frame
To determine any adverse effects associated with the use of low-dose steroids in this patient population.Timepoint: At baseline preoperatively, postoperative day 3, 1 month, 3 months and 6 months postoperatively.—

Countries

India

Contacts

Public ContactSoundarrajan D

Ganga hospital

soundarortho@gmail.com9994462230

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026