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24 hours versus 6 hours post partum magnesium sulphate therapy

Traditional (24 hours) versus Abbreviated (6 hours) post partum magnesium sulphate therapy in patients with pre eclampsia with severe features: A Randomized Controlled Trial - Post partum MgSO4 therapy

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/082251
Enrollment
90
Registered
2025-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O141- Severe pre-eclampsia

Interventions

Intervention1: Abbreviated post partum Magnesium sulphate therapy: Injection Magnesium sulphate infusion after delivery for 6 hours Control Intervention1: Traditional post partum Magnesium Sulphate th

Sponsors

ALL INDIA INSTITUTE OF MEDICAL SCIENCES JODHPUR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant women diagnosed with pre-eclampsia with severe features at more than 20 weeks gestation Severe pre-eclampsia diagnosed when A patient have arterial pressures of 140/90 mmHg or higher at least twice separated by 4 hours with or without proteinuria equal to or greater than 0.3gms and have one or more of the following clinical criteria Severe hypertension (160/110 mmHg), if Neurological symptoms, epigastric pain, or Laboratory abnormalities Increase in creatinine, Thrombocytopenia, Elevation of liver enzymes, When the woman was known to have chronic hypertension and have one of the aforementioned criteria plus the presence of proteinuria equal to or greater than 0.3 gm, it is considered pre eclampsia with severe features

Exclusion criteria

Exclusion criteria: 1. Eclampsia before delivery, 2. HELLP syndrome, 3. Epilepsy 4. Pre-eclampsia with additional pathology such as Renal failure, Acute pulmonary edema, Decompensated diabetes mellitus, Autoimmune diseases, or Hypertensive encephalopathy

Design outcomes

Primary

MeasureTime frame
Effectiveness of MgSo4Timepoint: 6 hrs Vs 24 hrs—

Secondary

MeasureTime frame
OBJECTIVES: To assess a) Total time of magnesium sulphate infusion prior to birth b) Postpartum hemorrhage, c) Maternal respiratory distress d) Time to onset of ambulation post partum and breastfeeding start time e) Use of antihypertensives drugs in postpartum period f) Number of seizures in post partum period & time and duration of postpartum convulsion if any g) Feto - maternal outcomeTimepoint: 72 hrs postpartum—

Countries

India

Contacts

Public ContactDR SHAHANA SHERIN PP

ALL INDIA INSTITUTE OF MEDICAL SCIENCES JODHPUR

jhirwalm@aiimsjodhpur.edu.in7042657811

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026