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Use of newer bioactive material for conservative treatment of deep carious lesion as a potential alternative to root canal treatment

Effectiveness of nanoceria in vital pulp therapy of carious exposed permanent teeth- An in vivo study - NIL

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/082178
Enrollment
75
Registered
2025-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Nanoceria or nanoceria with PRP: Nanomaterials (NMs) have recently gained significant attention in dentistry owing to their superior physical, mechanical, chemical, and biological prope

Sponsors

Dr Manasvi Sharma
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 and above who consent to sign the informed consent form. 2. Pulp sensibility testing (Thermal/Electrical Test) indicating a inflammed pulp. 3. Teeth with extensive caries affecting the pulp. 4. Teeth exhibiting Negative/Mild TOP (Tender On Percussion) and normal mobility. 5. Manifestation of pre-operative signs and symptoms of Reversible Pulpitis/Symptomatic Irreversible Pulpitis. 6. Minor periapical pathology or slight widening of PDL observed in radiographic evaluation. 7. The teeth should be suitable for immediate restoration with any permanent filling material.

Exclusion criteria

Exclusion criteria: o Patients with overall conditions that contraindicate dental procedures. o Teeth that have undergone previous VPT procedures or started root canal treatments. o Teeth accompanied by swelling, abscesses, fistulas, or unusual mobility. o Teeth exhibiting external or internal resorption, significant radiolucency around the apex or furcation, or calcification in the pulp chamber. o Teeth with cracks, periodontal disease, or fractured teeth. o Teeth that do not respond to pulp sensibility tests.

Design outcomes

Primary

MeasureTime frame
Patient responses like subjective & objective symptoms & signs. Pulp sensibility testing like Thermal or ElectricalTimepoint: one three and six months

Secondary

MeasureTime frame
Intraoral Periapical Radiographs to rule out development of any periapical pathology & to evaluate for any evidence of formation of dentinal bridgeTimepoint: six & nine months

Countries

India

Contacts

Public ContactDr Manasvi sharma

Subharti dental college and hospital,Subharti university Meerut

shikhajais18@yahoo.com9760707057

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026