Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: patients in the group received high dose iv tranexamic acid: patients in this group received high dose tranexamic acid (50mg/kg)
Control Intervention1: patients in the group received st
Sponsors
AIIMS Patna
Eligibility
Inclusion criteria
Inclusion criteria: 1.Skeletally mature patients with preop hemoglobin more than 10 mg/dl with vertebral fractures, degenerative disc diseases, spondylodiscitis who needs open spine surgery. 2.People with normal levels of PT with INR and Aptt levels
Exclusion criteria
Exclusion criteria: 1.Elevated PT, PTT, INR for any reason 2.Patients with cervical disc disease and cervical vertebral fracture who needs anterior cervical diskectomy and fusion. 3.Patients who need single level lumbar diskectomy, single level spine decompression for lumbar canal stenosis. 4.Patients with pathological fractures, intradural tumor and spine deformity 5.History of thrombotic events such as CVA and MI 6.History of bleeding disorder 7.History of traumatic brain injury and CPR 8.Cancer, or any other serious illness that affects treatment evaluation 9.Renal failure with GFR lower than 60 ml/min 10.Use of anticoagulants such as aspirin and dipyridamole 11.OCP consumption, pregnancy, or lactation 12.Revision spine surgery 13.Patient with intraoperative Dural tears
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Blood loss intraoperatively 2.Blood loss postoperatively Timepoint: 1.Intraoperatively 2.Postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.The complications associated with the use of Tranexamic acid in spine surgery. 2.Relation between TXA dosage with hospital stay. Timepoint: 1. Intraoperative 2. Postoperative | — |
Countries
India
Contacts
Public ContactPrabhat Agrawal
AIIMS PATNA
Outcome results
None listed