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Effectiveness of cough assist in addition to chest wall oscillation device on amount of sputum reduction and peak cough flow in COPD patients with acute exacerbation: A randomized controlled trial

Effectiveness of mechanical insufflation-exsufflation in addition to high frequency chest wall oscillation on sputum clearance and peak cough flow in COPD patients with acute exacerbation: A randomized controlled trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/082028
Enrollment
30
Registered
2025-03-10
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J441- Chronic obstructive pulmonary disease with (acute) exacerbation

Interventions

Intervention1: Intervention High Frequency Chest Wall Oscillation device along with Conventional Physiotherapy Treatment. Comparator, High frequency chest wall oscillation in addition to Mechanical

Sponsors

Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia
Lead Sponsor
Metro Centre for Respiratory Diseases
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: All the participants will be included based on the diagnosis of COPD according to spirometry value Forced expiratory volume in 1 sec and forced vital capacity ratio less than 0.70. COPD patients, GOLD stage II-IV. Daily sputum volume more than 20 ml daily at least 3 consecutive days . Peak cough flow (PCF) range below 270 litre per min. Participants must be willing and able to comply with the study protocol .

Exclusion criteria

Exclusion criteria: Patients will be excluded if they have need for invasive mechanical ventilation, bronchiectasis, active lung tuberculosis, chest wall trauma, thoracic or abdomi nal operation in the last three months. Patients who had unstable angina & acute Myocardial Infarction. Patients who present with Asthma and Asthma-COPD overlap syndrome (ACOS), and If they displayed unwillingness to implement the protocol.

Design outcomes

Primary

MeasureTime frame
Sputum Clearance efficacy, Peak Cough FlowTimepoint: Pre Intervention Baseline and Post Intervention—

Secondary

MeasureTime frame
Pulmonary Function Test (PFT), Arterial Blood Gas Analysis (ABG),HRQoL, Dyspnea severity.Timepoint: Pre Intervention Baseline and Post Intervention—

Countries

India

Contacts

Public ContactDr Priyanka Rani

Jamia Millia Islamia, New Delhi

aqsamuj786@gmail.com8130676908

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026