To Compare Chlorpheniramine Maleate and Butorphanol as Premedication Intravenously on Postoperative Agitation in Adult Patients Undergoing Otorhinolaryngeal Surgery.

Comparison of Effect of Intravenous Chlorpheniramine Maleate and Butorphanol as Premedication on Postoperative Agitation in Adult Patients Undergoing Otorhinolaryngeal Surgery. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/082026

Enrollment

Registered

2025-03-10

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H958- Other intraoperative and postprocedural complications and disorders of the ear and mastoid process, not elsewhere classified

Interventions

Intervention1: Chlorpheniramine: Patients will receive chlorpheniramine maleate 5mg diluted in 9ml isotonic saline IV 15 minutes preinduction. Control Intervention1: Butorphanol: Patient will receive

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists (ASA) grade I and II.

Exclusion criteria

Exclusion criteria: Known allergy to chlorpheniramine maleate or/and butorphanol. Patient with a history of neurological and psychiatric diseases. Body mass index more than 30 of the ideal. History of recent use of antihistaminic drugs. Auditory or vision disorders Pregnancy.

Design outcomes

Primary

Measure	Time frame
To compare the post operative agitation in patients receiving preemptive intravenous chlorpheniramine maleate and butorphanol undergoing otorhinolaryngeal surgeries under GA.Timepoint: 30 min after surgery	—

Secondary

Measure	Time frame
To assess the post operative agitation in patient receiving preemptive intravenous chlorpheniramine maleate undergoing Otorhinolaryngeal surgery under GA. To assess the post operative agitation in patient receiving preemptive intravenous butorphanol undergoing Otorhinolaryngeal surgery under GA.Timepoint: 30 min after surgery	—

Countries

India

Contacts

Public ContactAnkush Bains

GGSMCH,Faridkot

amanjotrajpal@gmail.com9814921142

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026