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To observe postoperative changes in heart rate and blood pressure and cough suppression on giving dexmedetomidine in the tube before taking off the patient from ventilator

Effect of intratracheal Dexmedetomidine to attenuate cardiovascular and airway responses to tracheal extubation. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/081994
Enrollment
90
Registered
2025-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Dexmedetomidine: Group D1- Patient will be administered Dexmedetomidine 0.3 mic/kg diluted till 2 ml with Normal saline intratracheally 30 min before extubation Intervention2: Dexmed

Sponsors

Christian Medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18-65 years Patients of ASA grade 1 and 2 Either sex Patients scheduled for general anaesthesia

Exclusion criteria

Exclusion criteria: Patients with recent upper respiratory tract infections Patients with uncontrolled or untreated hypothyroidism Patients with heart disorders like heart block, coronary heart disease Hepatic and renal insufficiency Patients on alpha 2 agonist and sedative drugs

Design outcomes

Primary

MeasureTime frame
After instillation of dexmedetomidine intratracheal following parameters will be measured Haemodynamic parameters- Heart rate,Blood pressure, SpO2, Adverse effects- Hypotension , breath holding, Bradycardia, emergence delirium Timepoint: At the time of instillation of dexmedetomidine , After drug intillation @ 5 min, 10 min, 20 min, 30 min

Secondary

MeasureTime frame
After extubation following parameters will be measured Haemodynamic parameters- Heart rate,Blood pressure, SpO2, Adverse effects- Hypotension , breath holding, Bradycardia, emergence delirium Timepoint: 1 min before extubation, At extubation, after extubation at 1 min, 5 min, 10 min, 20 min, 30 min; 1. Ramsay sedation score at the time of extubation : 2. Time to reach ramsay sedation score of 3: 3. Time from reversal to extubation: 4. Quality of extubation score : Timepoint:

Countries

India

Contacts

Public ContactDr Priyanka Garg

Christian Medical college and hospital,brown road, ludhiana

priyankagarg6996@gmail.com8699924222

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026