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Comparing the effect of root canal therapy and regrowth therapy for healing of infection

Comparative Evaluation of Regenerative endodontic procedure and conventional non-surgical endodontic procedure for treatment of necrosed mature permanent teeth with apical periodontitis - A Randomized Control Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/081947
Enrollment
58
Registered
2025-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A00-B99- Certain infectious and parasitic diseases

Interventions

Intervention1: Regenerative endodontic Procedure: Regenerative endodontic Procedure for treatment of necrosed mature permanent teeth in which blood clot will be induced in the patient after administer

Sponsors

Dr. Ashlesha Madankar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Permanent single rooted teeth with complete root formation are included. Permanent single rooted teeth with diagnosis of mature necrosed teeth with symptomatic apical periodontitis and Permanent single rooted teeth indicated for primary root canal treatment with Periapical Index Score (PAI) of equal to or more than 3 are included

Exclusion criteria

Exclusion criteria: Patients who are medically compromised are excluded.Patients who had taken antibiotics in last 1 month and Pregnant and lactating women are excluded.Immature teeth or teeth with root resorption and Teeth with calcified canals and Patients with generalized chronic periodontitis and Teeth with previous root canal treatment and Teeth with canal curvature more than 25 degree and Periodontal pocket larger than 3 mm are excluded

Design outcomes

Primary

MeasureTime frame
Reduction in Periapical Index Score radiographicallyTimepoint: 1,3,6 and 12 months

Secondary

MeasureTime frame
CLINICAL EVALUATION (Presence of vitality, swelling, sinus tract with spontaneous, palpation or percussion pain)Timepoint: 1,3,6 and 12 months

Countries

India

Contacts

Public ContactDr Sulabha Radke

Government Dental College and Hospital, Nagpur

sulabharadke@gmail.com9823262628

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026