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To compare the effect of Dexmedetomidine with Magnesium Sulphate by Nebulization to attenuate hemodynamic stress response to Intubation in Patients undergoing elective surgery under General Anaesthesia

Comparative Evaluation Of Dexmedetomidine versus Magnesium Sulphate by Nebulization to attenuate hemodynamic stress response to Intubation in Patients undergoing elective surgery under General Anaesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/081941
Enrollment
120
Registered
2025-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K95- Diseases of the digestive system Health Condition 2: K631- Perforation of intestine (nontraumatic) Health Condition 3: N63- Unspecified lump in breast Health Condition 4: K80- Cholelithiasis

Interventions

Intervention1: Dexmedetomidine: Dexmedetomidine in a dose of 1 mcg/kg will be diluted in normal saline up to 5 ml, and nebulisation will be done with oxygen at a rate of 8-10 l/min, 15 to 20 min befor

Sponsors

Guru Gobind Singh Medical College Hospital
Lead Sponsor
DrGagandeep
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing surgeries under general anaesthesia. 2. Patients of age group between 18 to 65 years of either gender. 3. American Society of Anaesthesiologist grade I and II.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of allergy to the study drugs. 2. Patients in whom intubation time exceeded 20 seconds or in cases where first attempt to intubate has failed. 3. Refusal of consent. 4. Patients with body mass index (BMI) more than 30 kg/m2, a history of cardiovascular diseases like ischaemic heart disease and uncontrolled hypertension, a history of alcohol intake, chronic analgesic or drug abuse, and pregnant patients will be excluded from the study. 5. Patients with difficult airway (for example: mouth opening less than 2 fingers, MPG more than 2, 6. Neck movement: flexion / extension -limited).

Design outcomes

Primary

MeasureTime frame
To evaluate the alteration in the hemodynamic stress response to intubation in terms of Systolic Blood Pressure with nebulized dexmedetomidine (1ug/kg) To evaluate the alteration in the hemodynamic stress response to intubation in terms of Systolic Blood Pressure with nebulized magnesium sulphate (30mg/kg)Timepoint: Baseline,immediately after nebulization,1 minute after tracheal intubation, 5 minutes after tracheal intubation,10 minutes after tracheal intubation—

Secondary

MeasureTime frame
to compare the DBP, HR, MAP, SpO2 with nebulized dexmedetomidine (1ug/kg) and with nebulized magnesium sulphate (30mg/kg)Timepoint: Till 10 mins of intubation;To compare the incidence of hypotension, bradycardia or sedation after nebulization with Dexmedetomidine and Magnesium SulphateTimepoint: Till the end of surgery—

Countries

India

Contacts

Public ContactDr Kewal Krishan Gupta

GGSMCH,Faridkot

doc_krishan31@yahoo.co.in9781812052

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026