A clinical trial to evaluate the effect of magnesium sulfate with local anaesthetic injection for tooth pain during and after root canal treatment

Analgesic efficacy of 2% Lignocaine and 4% Articaine with or without Magnesium Sulfate for inferior alveolar nerve block in irreversible pulpitis and apical periodontitis -A Randomized Clinical trail - LAMS

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/081928

Enrollment

Registered

2025-03-07

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 2% lidocaine with 1:80,000 epinephrine and 4% articaine with 1:1,00,000 epinephrine and 75 mg magnesium sulfate: Pre-operative vitals and Heft Parker Visual Analogue Scale (HP-VAS) pain

Eligibility

Inclusion criteria

Inclusion criteria: Patients those who will be diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis of mandibular molar teeth were included into the study. ASA category I, II Patient age group 20-60

Exclusion criteria

Exclusion criteria: Exclusion criteria included ASA category III and above, patients with any prior medications, those allergic to LA, pregnant, and lactating women

Design outcomes

Primary

Measure	Time frame
anesthetic and post operative analgesic efficacy expected with addition of magnesium sulfateTimepoint: anesthetic and post operative analgesic efficacy expected with addition of magnesium sulfate. The onset of anaesthesia will be evaluated by EPT for every 1 min until the corresponding vital tooth stops responding. Lip numbness will be considered to check the aesthetic success within 15 minutes.The duration of anaesthesia will be evaluated every 15 min using EPT till the adjacent normal tooth responded on the working side.	—

Measure

Time frame

anesthetic and post operative analgesic efficacy expected with addition of magnesium sulfateTimepoint: anesthetic and post operative analgesic efficacy expected with addition of magnesium sulfate. The onset of anaesthesia will be evaluated by EPT for every 1 min until the corresponding vital tooth stops responding. Lip numbness will be considered to check the aesthetic success within 15 minutes.The duration of anaesthesia will be evaluated every 15 min using EPT till the adjacent normal tooth responded on the working side.

—

Secondary

Measure	Time frame
post operative analgesic efficacy expected with addition of magnesium sulfateTimepoint: anesthetic efficacy expected with addition of magnesium sulfate. Pain data will be collected after access cavity and insertion of files in the canals. The post-operative analgesia will be examined at intervals of 6, 12, 24, and 48 h.	—

Countries

India

Contacts

Public ContactDr. Sadasiva K

Chettinad Dental College and Research Institute

charanya1711@gmail.com47411000

Outcome results