Health Condition 1: S062- Diffuse traumatic brain injury
Conditions
Interventions
Intervention1: Intermittent theta burst stimulation: A type of rTMS, given at 600 pulses at left DLPFC at 80% of RMT, given as daily sessions of 12 sittings over 2 weeks. Each session lasts about 3 mi
Sponsors
National Institute of Mental Health and Neuro Sciences
Eligibility
Inclusion criteria
Inclusion criteria: With diffuse axonal injury on MRI brain having disorders of consciousness diagnosed clinically by the neurosurgery team and by the Coma Recovery Scale-Revised Diagnosis of diffuse axonal injury made within 6 months, and patients having at least 2 weeks of disorders of consciousness after stabilization of acute condition Managed in the head injury ward Hemodynamically stable medical condition
Exclusion criteria
Exclusion criteria: History of epilepsy or unprovoked seizures. Presence of metallic implants or pacemakers. Pregnant women History of substance dependance in the last 1 month. Disorders of consciousness due to other causes Skull defects due to craniotomy Those requiring assistance of ventilator Those requiring ICU care
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility, safety and tolerability of iTBS in patients of diffuse axonal injury with disorders of consciousnessTimepoint: Baseline assessments for consciousness, at start, midway, end of sessions and at 3 and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of consciousness with this protocol in such patientsTimepoint: Baseline assessments for consciousness, at start, midway, end of sessions and at 3 and 6 months | — |
Countries
India
Contacts
Public ContactTabassum Rahman
National Institute of Mental Health and Neuro Sciences
Outcome results
None listed