In patients undergoing elective surgery under general anesthesia, a research comparing the effects of Intravenous dexmedetomidine, nebulized lidocaine, and a combination of the two on hemodynamic response for intubation

A Randomized study to compare the effect of Intravenous Dexmedetomidine versus Nebulized Lidocaine versus combination of Intravenous Dexmedetomidine with Nebulized Lidocaine on hemodynamic response for intubation in patients undergoing elective surgery under general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/081809

Enrollment

Registered

2025-03-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs

Interventions

Intervention1: GROUP C: Patients will receive nebulized lidocaine 4% (2 mg/kg): Group C will receive nebulization via a face mask with lidocaine 4% (2mg/kg) diluted with NS (total volume 5ml) with oxy

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient undergoing elective surgery under general anaesthesia requiring endotracheal intubation 2.Patients consenting to participate 3.Adult patients 4.Patients belonging to American Society of Anesthesiologists (ASA) grade I and II

Exclusion criteria

Exclusion criteria: 1.Patient should not be a part of other study 2.Non co-operative patient 3.Patients with difficult airway 4.Patients with cardiorespiratory comorbidity 5.Patients with smoking history 6.Patients on antihypertensive medication

Design outcomes

Primary

Measure	Time frame
To determine the change in Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure and Rate Pressure Product within three groupsTimepoint: To determine the change in Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure and Rate Pressure Product within three groups at 1, 3, 5, 7 and 10 minutes post intubation	—

Secondary

Measure	Time frame
To assess the side effects.Timepoint: After completion of surgery the side effects like bradycardia, hypotension, bitter taste, dysphonia and oropharyngeal numbness within three.	—

Countries

India

Contacts

Public ContactDr Harshawarthan P

Sawai Man Singh Medical College, Jaipur

drmamtakhandelwal@gmail.com9929338174

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026