Comparison of two different doses of Morphine with Levobupivacaine administered in spinal anaesthesia for pain relief after surgery in patients undergoing knee replacement.

Comparison of two different doses of intrathecal Morphine as an adjuvant to 0.5% heavy Levobupivacaine for postoperative analgesia in patients undergoing Total knee replacement. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/081806

Enrollment

Registered

2025-03-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: morphine + 0.5% heavy Levobupivacaine: Intrathecal morphine 200 mcg + Intrathecal 0.5% heavy Levobupivacaine 15 mg To be given to 35 patients undergoing TKR Control Intervention1: mor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age from 18 to 75 yrs 2. All genders 3. ASA Physical status I – III 4. All patients placed for Elective Total Knee Replacement under Spinal Anaesthesia

Exclusion criteria

Exclusion criteria: 1. Uncontrolled co-morbidities like hypertension, Diabetes, Heart Disease 2. Opioid addicts 3. Patients already on opioids. 4. All contraindications for spinal anaesthesia. 5. Pregnant and Lactating females. 6. Mentally retarded.

Design outcomes

Primary

Measure	Time frame
1.To compare the duration of post operative analgesia amongst two groups using Visual Analogue Scale(VAS) score. 2.To compare time to first rescue analgesic in both groups. Timepoint: 0, 2hr, 4hr, 8hr, 12hr, 16hr, 24hr	—

Secondary

Measure	Time frame
1. Comparison of effect on Onset and Duration of Sensory and Motor Block in both group 2. Peri-operative hemodynamic monitoring- HR, BP, RR, SpO2 within 24 hrs 3. Comparison of occurrence of Adverse Reactions (nausea/vomiting, pruritis , urinary retention, constipation, respiratory depression ) within 24 hrs after surgery in either group. Timepoint: Peri-operative hemodynamic monitoring - 1. Intra-operatively : every 5 min 2. Post-operatively : 2hr, 4hr, 8hr, 12hr, 16hr, 24hr	—

Measure

Time frame

1. Comparison of effect on Onset and Duration of Sensory and Motor Block in both group 2. Peri-operative hemodynamic monitoring- HR, BP, RR, SpO2 within 24 hrs 3. Comparison of occurrence of Adverse Reactions (nausea/vomiting, pruritis , urinary retention, constipation, respiratory depression ) within 24 hrs after surgery in either group. Timepoint: Peri-operative hemodynamic monitoring - 1. Intra-operatively : every 5 min 2. Post-operatively : 2hr, 4hr, 8hr, 12hr, 16hr, 24hr

—

Countries

India

Contacts

Public ContactDr Sapna Singh

Mahatma Gandhi Medical College and Hospital

sapnamp93@gmail.com9829141123

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026