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Can Aspirin Boost Bone Regeneration? Exploring its role in enhancing L-PRF Blocks for bone regeneration in periodontal disease Treatment

Does Aspirin enhance the regenerative capacity of L-PRF Block in the treatment of intrabony defects. A parallel design, double arm, non-inferiority randomized clinical trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/081739
Enrollment
20
Registered
2025-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K055- Other periodontal diseases

Interventions

Intervention1: L-PRF BLOCK: 10 ml blood will be obtained from patient. One Vacutainer containing 3ml blood will be placed in a swing rotor centrifuge. Centrifugation will be done at 2700 rpm for 3 min

Sponsors

DR ATHIYA FATHIMA A
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: STAGE 3 GRADE A PERIODONTITIS PATIENTS BOP More than 15% bleeding sites. Minimum of 20 teeth, excluding third molars to be present. Patients with good general health. Non-smokers.

Exclusion criteria

Exclusion criteria: Any systemic or debilitating disease affecting periodontal and bone health (e.g., Diabetes). Immunocompromised patients (HIV infected). Regular anti-inflammatory medication use (NSAIDS or Aspirin). Regular intake of any medication that affects bone metabolism (vitamin D supplements). Antimicrobial use in the last three months. Surgical periodontal treatment in the last six months. Teeth with root caries (active or filled). Endodontically treated teeth. Allergy to aspirin.

Design outcomes

Primary

MeasureTime frame
RADIOGRAPHIC PARAMETER OF VERTICAL DEFECT ON CBCTTimepoint: BASELINE (0 MONTH) 6 MONTHS

Secondary

MeasureTime frame
Gingival index ( Loe and Silness 1963) Plaque index (Turesky-Gilmore-Glickman modification of Quigley Hein plaque index 1970) Probing pocket depth Clinical attachment level Relative attachment level Timepoint: Baseline 1 MONTH 3 MONTH 6 MONTH

Countries

India

Contacts

Public ContactDR ATHIYA FATHIMA A

BANGALORE INSTITUTE OF DENTAL SCIENCES

docranga@gmail.com9486482686

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026