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preoperative nebulization with ketamine will be compared with lignocaine in patients undergoing general anaesthesia in prevention of sore throat.

Comparison of preoperative nebulization with lignocaine versus ketamine in prevention of sore throat in patients undergoing general anaesthesia - nil

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/081734
Enrollment
300
Registered
2025-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Normal Saline: 2 ml of normal saline nebulisation 15 minutes prior shifting to O.T. Intervention2: Normal Saline 0.9%: Intensity of Post operative sore throat in patients undergoing gen

Sponsors

Shivani Sharma
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) ASA grade 1 and 2 2) Age : Between the ages of 18 and 70, enrolled for elective surgery required for 2 hours of endotracheal intubation while under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1) Patient that decline for participation in trial. 2) Patient allergic to ketamine or lignocaine. 3) Patient cough or bucked during intubation and extubation. 4) BMI more than 35 kg/ meter square. 5) Patient with history of previous sore throat or taking steroids or analgesia in last 48 hours 6) COPD, asthma, neuromuscular disease, difficult intubation.

Design outcomes

Primary

MeasureTime frame
To assess and compare the intensity of Post-Operative sore throat in patients with Pre-Operative nebulization with lignocaine and ketamine undergoing general anaesthesia with endotracheal intubation.Timepoint: Hemodynamic variables will continued to be monitored at baseline to 4 hours, 6 hours, 12 hours and then 24 hours.

Secondary

MeasureTime frame
To evaluate the hemodynamic alterations and side effects, such as sedation, dry mouth, nausea, cough and vomiting during the study.Timepoint: 24 hours

Countries

India

Contacts

Public ContactDr Shivani sharma

Maharishi Markandeshwar Medical College

drbsekhon@gmail.com9814030551

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026