Norepinephrine or Epinephrine: Which is Better for Children in Post-Cardiac Arrest Shock?

Comparison of the efficacy of Epinephrine vs. Norepinephrine in clinical outcomes among children with Post-Cardiac arrest shock:A Hospital based, open-label, Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/081706

Enrollment

Registered

2025-03-05

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I468- Cardiac arrest due to other underlying condition

Interventions

Intervention1: Norepinephrine infusion: Route of administration: continuous intravenous infusion Starting dose: 0.1 mcg/kg/min Maximum dose: 0.3 mcg/kg/min Time intervals: The dose will be increased

Eligibility

Inclusion criteria

Inclusion criteria: All children aged between 1month to 18 years who present to the pediatric emergency in cardiac arrest (OHCA) “or ? children admitted under the Department of Paediatrics who are not on any ionotropic support develops cardiac arrest due to a non-cardiac cause, “and ? achieves return of spontaneous circulation (ROSC) after the resuscitation “and ? exhibiting features of post-resuscitation shock.

Exclusion criteria

Exclusion criteria: 1. Preexisting cardiac disease 2. Parents not willing to provide consent for this study.

Design outcomes

Primary

Measure	Time frame
To compare the incidence of in-hospital mortality between the two groups receiving norepinephrine and epinephrine.Timepoint: less than 24 hours, 24 hours to 7 days, 7 days to 30 days.	—

Secondary

Measure	Time frame
To determine the duration of vasopressor support required for hemodynamic stabilization in each treatment group.Timepoint: Time Required for Shock Resolution Following the Initiation of Inotropes, Assessed at 15-minute Intervals;To compare the effects of norepinephrine and epinephrine on mean arterial pressure(MAP) in children with post-cardiac arrest shock.Timepoint: Comparing the mean arterial pressure (MAP) at 15 minutes, 30 minutes, and 45 minutes after starting inotropes;To analyze the neurological outcomes at hospital discharge using the Cerebral Performance Category (CPC) scale.Timepoint: Neurological outcome will be assessed at the time of discharge;To evaluate the occurrence of arrhythmias and catecholamine resistant shock in patients treated with either vasopressor.Timepoint: The occurrence of arrhythmias and the development of catecholamine-resistant shock will be monitored until the resolution of shock and the discontinuation of inotropes and vasopressors.	—

Measure

Time frame

To determine the duration of vasopressor support required for hemodynamic stabilization in each treatment group.Timepoint: Time Required for Shock Resolution Following the Initiation of Inotropes, Assessed at 15-minute Intervals;To compare the effects of norepinephrine and epinephrine on mean arterial pressure(MAP) in children with post-cardiac arrest shock.Timepoint: Comparing the mean arterial pressure (MAP) at 15 minutes, 30 minutes, and 45 minutes after starting inotropes;To analyze the neurological outcomes at hospital discharge using the Cerebral Performance Category (CPC) scale.Timepoint: Neurological outcome will be assessed at the time of discharge;To evaluate the occurrence of arrhythmias and catecholamine resistant shock in patients treated with either vasopressor.Timepoint: The occurrence of arrhythmias and the development of catecholamine-resistant shock will be monitored until the resolution of shock and the discontinuation of inotropes and vasopressors.

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Countries

India

Contacts

Public ContactDr Arun Prasad

All India Institute of Medical Sciences, Patna

drarunp@aiimspatna.org9472140820

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026