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An open labelled comparative study to the assess the effectiveness of sphenopalatine ganglion block given on both sides under ultrasound guidance to provide pain relief in pituitary tumors surgery done through the nose.

EFFECTIVENESS OF BILATERAL ULTRASOUND GUIDED SPHENOPALATINE BLOCK FOR INTRAOPERATIVE ANALGESIA IN ENDOSCOPIC TRANS-NASAL TRANS-SPHENOIDAL RESECTION OF PITUITARY TUMOR UNDER GENERAL ANAESTHESIA: AN OPEN LABEL COMPARATIVE STUDY. - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/081703
Enrollment
86
Registered
2025-03-05
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D352- Benign neoplasm of pituitary gland

Interventions

Intervention1: Ultrasound guided bilateral sphenopalatine ganglion block: In patients who are undergoing endoscopic trans-nasal trans-sphenoidal approach for resection of pituitary macroadenoma we wil

Sponsors

NIMHANS hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All adult patients scheduled for elective endoscopic Trans-nasal Trans-sphenoidal approach for resection of pituitary tumor will be included in the study.

Exclusion criteria

Exclusion criteria: Patients who refuse to give consent, Pre-exisiting Uncontrolled hypertension and diabetes, Coagulopathy or bleeding tendency, Pre-operative Glasgow Coma Scale <15, those who receive dexmedetomidine infusions intraoperatively

Design outcomes

Primary

MeasureTime frame
To compare the intra-operative pain (using Analgesia Nociceptive Index) and opioid consumption in patients undergoing Endoscopic Trans-nasal Trans-sphenoidal Resection of pituitary tumors receiving bilateral USG guided SPG block vs no block.Timepoint: Data (HR, MAP, SPI, ANIi and ANIm) will be collected every minute for five minutes (T1 T5) prior to and after the noxious stimuli during surgery.—

Secondary

MeasureTime frame
1) To compare intra-operative Analgesia Nociception Index (ANI) & Surgical Pleth Index (SPI) with the hemodynamic parameters at various stages of noxious stimulus within the group & between the groups. 2) To compare rescue analgesia between the groups during intraoperative period & up to 48 hours after the surgery. 3) To compare the adverse events between the groups (Intraoperative Bleeding, delayed recovery, PONV) 4) To compare the recovery characteristics at PACU between the groups (modified Aldrette score) & Pain score- NRSTimepoint: NSR will be assessed at immediate post-op, 4 hours, 24 hours & 48 hours—

Countries

India

Contacts

Public ContactDr Gopala Krishna K N

National Institute of Mental Health and Neuro Sciences

gops868@gmail.com9916469626

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026