Lumbar Triamcinolone will be compared with lumbar Dexamethasone to assess pain relief in patients with PIVD

To study the effectiveness of lumbar epidural dexamethasone with bupivacaine versus triamcinolone with bupivacaine in patients with prolapsed intervertebral disc - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/081699

Enrollment

100

Registered

2025-03-05

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: BUPIVACAINE WITH DEXAMETHASONE: 8mg Dexamethasone+ 0.125% Bupivacaine with Normal saline, total 10ml drug volume is given as lumbar epidural analgesia. Intervention2: BUPIVACAINE WITH T

Eligibility

Inclusion criteria

Inclusion criteria: 1.Individuals aged 18-70 years 2.Failed conservative treatment of PIVD for over 6 weeks 3. Chronic lumbar radiculopathy 4. Radiographic imaging (such as CT-scan or MRI) indicating the presence of either a herniated disc causing irritation or compression of a nerve root.

Exclusion criteria

Exclusion criteria: 1. Contraindications to the procedure itself, including active, local, or systemic infection, unstable medical conditions, coagulopathy, or the use of anti-thrombotic or anti-platelet medication, excluding aspirin, and allergy to contrast medium or injected medication. 2. Presence of cauda equina syndrome. 3. Back and lower extremity pain attributed to tumour origin, infections, or inflammatory pathologies of back. 4. History of prior low back surgery. 5. Pregnancy or nursing.

Design outcomes

Primary

Measure	Time frame
To systematically evaluate and compare the therapeutic effectiveness of lumbar epidural route injections containing dexamethasone versus triamcinolone in managing pain and enhancing functional outcomes in patients diagnosed with prolapsed intervertebral disc.Timepoint: results will enable us to assess and contrast the proportion of patients experiencing over 50% pain relief at designated follow-up time points of 1 hour, 24 hours, 15 days, 1 month and 3 month utilizing the VAS (Visual Analog Scale) Score.	—

Measure

Time frame

To systematically evaluate and compare the therapeutic effectiveness of lumbar epidural route injections containing dexamethasone versus triamcinolone in managing pain and enhancing functional outcomes in patients diagnosed with prolapsed intervertebral disc.Timepoint: results will enable us to assess and contrast the proportion of patients experiencing over 50% pain relief at designated follow-up time points of 1 hour, 24 hours, 15 days, 1 month and 3 month utilizing the VAS (Visual Analog Scale) Score.

—

Secondary

Measure	Time frame
Compare particulate steroids versus non particulate steroid for pain relief, and duration of Pain Relief.Timepoint: Successful treatment outcome will be considered in patients with 50% reduction in VAS score from baseline after 3 months.	—

Countries

India

Contacts

Public ContactDr Smriti Anand

Maharishi Markandeshwar Medical College and Hospital, Kumarhatti

gupta.smriti1@gmail.com9418079103

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026