To compare gingival health around two types of implant crowns

A one-year Split-Mouth Randomized Controlled Trial to evaluate peri-implant mucosal health after cementation of Ultra-polished Zirconia crown compared with Conventionally polished Zirconia crown using periodontal indices (BOP, PD, PI) and Gingival biomarkers i.e. TNF-a and IL-1ß - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/081697

Enrollment

Registered

2025-03-05

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: Effect of Ultra Polished Zirconia Implant Crowns on Gingival Health: Zirconia crowns will be polished using the zirconia polishing kit Conventional polishing After conventional polishin

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients requiring placement of implants for replacement of bilateral missing tooth site bound by natural teeth. 2.Adequate amount of available bone for placement of dental implant. 3.Well healed partially edentulous site 4.Good oral hygiene and periodontal status of remaining dentition. 5.Available for follow up. 6.With positive informed consent. 7.Both the edentulous areas having antagonist teeth.

Exclusion criteria

Exclusion criteria: 1 Bone metabolic disorders affecting surrounding bone health 2 Vertical soft tissue thickness of less than 2 mm in the implant site 3 History of radiotherapy in head and neck region 4 Current habit of smoking or alcohol or drug abuse 5 Systemic conditions and auto immune disorders that might affect the integrity of implant or connective tissue health surrounding the implant 6 Blood disorders such as Haemophilia sickle cell anaemia thrombocytopenia 7 Signs of infection in the prospective implant site or retained root 8 Pregnancy or lactating mothers at the time of enrolment 9 Parafunctional habits such as bruxism and clenching 10 Local limitations such as inadequate inter ridge distance or mesiodistal space

Design outcomes

Primary

Measure	Time frame
1 To compare the gingival health between the study arms at time 1 month after cementation using Pocket Depth Plaque Index and using biomarkers TNF Aplha and IL 1 Beta 2.To compare the gingival health between the study arms at time 1 year after cementation using Pocket depth Plaque Index and using biomarkers TNF Aplha and IL 1 Beta Timepoint: Baseline 4 weeks 52 weeks	—

Secondary

Measure	Time frame
1.To assess gingival health using BOP, PD, PI and using biomarker TNF- a and IL-1ß just before cementation(T0), immediately1 month after cementation(T1) and at 1 year after cementation (T2) in the intervention arm of Ultra polished Zirconia crown 2.To assess gingival health using BOP, PD, PI and using biomarker TNF- a and IL-1ß just before cementation(T0), immediately1 month after cementation(T1) and at 1 year after cementation (T2) in the control arm of conventionally polished Zirconia crown Timepoint: 1 month and 1 year	—

Measure

Time frame

1.To assess gingival health using BOP, PD, PI and using biomarker TNF- a and IL-1ß just before cementation(T0), immediately1 month after cementation(T1) and at 1 year after cementation (T2) in the intervention arm of Ultra polished Zirconia crown 2.To assess gingival health using BOP, PD, PI and using biomarker TNF- a and IL-1ß just before cementation(T0), immediately1 month after cementation(T1) and at 1 year after cementation (T2) in the control arm of conventionally polished Zirconia crown Timepoint: 1 month and 1 year

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Countries

India

Contacts

Public ContactProf Veena Jain

CDER, AIIMS, New Delhi

jainveena1@gmail.com9868187441

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026