Health Condition 1: 4- Measurement and Monitoring Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Sugammadex with Vecuronium Top-up: Reversibility from general anaesthesia with Vecuronium top-up after administration of 2mg/kg Sugammadex intravenously
Control Intervention1: Sugammade
Sponsors
Datta Meghe Institute of Higher Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 years to 70 years ASA grade I/II/III Patient willing to participate in the study Surgery under general anaesthesia Duration 3 to 5 hours
Exclusion criteria
Exclusion criteria: Lack of valif informed written consent ASA grade IV Patients on medication known to interact with neuromuscular blocking drugs, eg.Antibiotics (aminoglycosides, tetracycline), antidepressants, anticonvulsants, antiarrhythmics (calcium channel blockers and quinidine) and magnesium sulphate and patients with known allergy to sugammadex.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reversibility from general anaesthesia when TOF 4 appears after administration of sugammadex in intermittent top-up and continuous infusion of vecuronium.Timepoint: From time of administration of sugammadex to 30 min after administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Time required for complete reversal using TOF.Timepoint: Base line - time at which reversal drug was given. end time - time at which TOF ratio of 0.9 is achieved. | — |
Countries
India
Contacts
Public ContactDr SNEHAL KABRA
Datta Meghe Institute of Higher Education and Research
Outcome results
None listed