Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue
Conditions
Interventions
Intervention1: Group 1 - intra articular injection of platelet rich plasma: Patients will be recruited from the OPD after applying ACR criteria & KL Grade Il and Ill on X-RAY KNEE AP/LAT (STANDING) an
Sponsors
Teerthanker Mahaveer Medical College and Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients over 18 years of age who had been diagnosed with osteoarthritis of the knee according to the American College of Rheumatology (ACR) 2019 criteria were included in this study. 2) Among these patients, only those diagnosed with Grade II and Grade III osteoarthritis of the knee joint, as classified by the Kellgren-Lawrence scale
Exclusion criteria
Exclusion criteria: a. Any known malignancy. b. Gouty Arthritis /inflammatory arthritis, Secondary Osteoarthritis c. Active knee infection. d. Disorders of Bleeding e. Uncontrolled Diabetes Mellitus f. Ligamentous instability of knee (MRI DIAGNOSED) g. Contraindication to MRI h. Any history of previous intraarticular steroid injection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To assess and compare the functional outcome in patients of Knee Osteoarthritis before each PRP/NS Injection and at 6 months and at 9 months and study their effect. 2.To assess and compare the Radiological outcome with the help of WORMS score and X-Ray in patients of Knee Ostenarthritis and observe the chances at the end of 9 months.Timepoint: 1,2,6 and 9 month | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the change in biomarker of cartilage degeneration (serum Coll2-1No2)(8) values after IA PRP injection & IA NS injection with the clinical improvement seen after the intervention.Timepoint: 9 months;To compare the articular cartilage changes on specialized MRI sequences(WORMS)(9) before and after the interventionTimepoint: Before intervention and after 9 month | — |
Countries
India
Contacts
Public ContactDr Amit Saraf
Outcome results
None listed