Health Condition 1: K850- Idiopathic acute pancreatitis
Conditions
Interventions
Intervention1: Garlic: Garlic capsules 600 mg twice daily orally for 6 months
Control Intervention1: Placebo: Identical looking placebo capsule twice daily orally for 6 months
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of recurrent acute pancreatitis 2. At least one episode of acute pancreatitis within last 90 days.
Exclusion criteria
Exclusion criteria: 1. Established chronic pancreatitis 2. Pregnancy or breast feeding 3. Age less than 12 years or more than 75 years 4. Patient already taking more than or equal to 1 gm garlic at least three days in a week 5. Biliary etiology or alcoholic etiology of pancreatitis 6. Major comorbidity such as decompensated cirrhosis, advanced heart failure (stage D), significant lung parenchymal or airway disease with NYHA grade more than or equal to 3, advanced chronic kidney disease (stage more than or equal to 4), untreated HIV infection, untreated cancer. 7. Not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in abdominal pain over 1 year in patients with recurrent acute pancreatitis with Garlic (Allium sativum) therapy for 6 months as compared to placebo.Timepoint: Reduction in abdominal pain over 1 year in patients with recurrent acute pancreatitis with Garlic (Allium sativum) therapy for 6 months as compared to placebo. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of painful days over 1 year.Timepoint: 1 year;Number of episodes of acute pancreatitis over 1 yearTimepoint: 1 year;Progression to Chronic PancreatitisTimepoint: 1 year;Quality of life as per SF-36 questionnaireTimepoint: 6 months;Adverse eventsTimepoint: 6 months | — |
Countries
India
Contacts
Public ContactDr Soumya Jagannath Mahapatra
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed