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Prophylactic fixed rate phenylephrine versus norepinephrine infusion for the prevention post spinal hypotension during lower abdominal surgery

Prophylactic fixed-rate phenylephrine versus norepinephrine infusion for the prevention of post-spinal anesthesia hypotension during lower abdomen surgeries a prospective double blinded randomised controlled trial - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/081439
Enrollment
180
Registered
2025-02-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Prophylatic pre fixed Noradrenaline in prevention of post spinal hypotension: Pre-anaesthetic check-up of each patient will be done with detailed history, complete physical examination

Sponsors

Dr SYED FAZIL A
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 patients

Exclusion criteria

Exclusion criteria: Patient s refusal Infection at the site Coagulation abnormalities Allergy to the study drug(s) Repeat spinal or failed spinal Pregnant females Known case of hypertension Heart rate increased or decreased 20% from baseline Cardio Vascular diseases Sensory loss above T6 level

Design outcomes

Primary

MeasureTime frame
To compare the efficacy and safety profile of pre emptive phenylephrine vs noradrenalinefor prevention of hypotension during spinal anesthesia in lower abdominal surgeryTimepoint: Prophylatic infusion is given 10 min prior to spinal and monitoring ( BP, Saturation,heart rate and mean arterial pressure)is done for every 3 min for first 30 min and then every 5 min until completion of surgery

Secondary

MeasureTime frame
To study hemodynamic stability between both drugs Use of mephentermine (rescue bolus) requirement Side effects & complications if any between both groupsTimepoint: Patient will be monitored for 2 hours after surgery for any complications & vitals monitoring

Countries

India

Contacts

Public ContactDr Vikram vardhan

ALL INDIA INSTITUTE OF MEDICAL SCIENCE GORAKHPUR

vikram15vardhan@gmail.com93232 67123

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026