Health Condition 1: K807- Calculus of gallbladder and bile duct without cholecystitis Health Condition 2: C509- Malignant neoplasm of breast of unspecified site Health Condition 3: C269- Malignant neoplasm of ill-definedsites within the digestive system
Conditions
Interventions
Intervention1: Direct Laryngoscopy and Tracheal Intubation: Premedication 60 min prior to procedure
Control Intervention1: Oral Melatonin vs Oral Clonidine vs Oral Pregabalin: Effect of Oral Melatonin
Sponsors
Sardar Patel Medical College Bikaner
Eligibility
Inclusion criteria
Inclusion criteria: Elective surgery under general endotracheal anesthesia
Exclusion criteria
Exclusion criteria: 1. Anticipated difficult intubation. 2. Modified Mallampati grade III/IV. 3. Patient s refusal to participate in the study. 4. Patient receiving treatment with either of the study drug i.e., Melatonin or Clonidine; or having any known allergy to these drugs. 5. Patients receiving treatment for any cardiac illness, pregnancy, renal disease, liver disease, morbid obesity, bleeding disorder, thyroid disorder, etc. 6. Patients on anti-hypertensives, oral hypoglycemic, anti-depressants, anti-convulsant, anti-psychotics, thyroid medications, and birth control pills. 7. Pregnant and lactating females. 8. Patients with prolonged laryngoscopy time (more than 30 s)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To Compare Effect of Oral Melatonin, Oral Clonidine and Oral Pregabalin Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation. Hemodynamic changes like HR, SBP, DBP and MBPTimepoint: At baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Requirement of intraoperative rescue Propofol doses and need for antihypertensive drug. Post-operative side effects. Timepoint: Till the drug effect is over | — |
Countries
India
Contacts
Public ContactDr Anita Pareek
Sardar Patel Medical College Bikaner Rajasthan India
Outcome results
None listed