Health Condition 1: A170- Tuberculous meningitis
Conditions
Interventions
Intervention1: Intrathecal Injection Hyaluronidase: Under all aseptic conditions, Lumbar Puncture will be done at L3-L4 or L4-L5 level by using 22G spinal needle. Confirmation of Lumbar Puncture will
Sponsors
AIIMS Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: 1. New cases of tuberculous meningitis diagnosed using clinical, CSF and radiological finding having focal weakness, atrophy, diminished or absent deep tendon reflexes, vision impairment or imaging evidence of basal exudate or optochiasmatic arachnoiditis or spinal arachnoiditis. 2. Within one month of starting antitubercular treatment. 3. Age 18 year or older of both genders.
Exclusion criteria
Exclusion criteria: 1. Confirmed meningitis other than Tuberculosis. 2. Pregnancy 3. Premorbid (prior to the onset of present illness ) mRS 4 or more 4. Patients with gross spinal deformity where Lumbar Puncture is technically difficult. 5. History of severe hypersensitivity reaction to drugs 6. Patients with terminal illness/palliation whose life expectancy is 6 months or less.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in disability measured by Barthel Index score improvement of at least 2 points (at 3 month)Timepoint: 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Radiological resolution of arachnoiditis and non-development of other CNS complications (evaluated by follow up MRI scan of brain and spine) at 3months. 2.Reduction in Lindegaard ratio at 3 months as measured by TCD 3.Drug related adverse effects. Timepoint: 3 months | — |
Countries
India
Contacts
Public ContactDr Tathagata Ghosh
AIIMS Bhubaneswar
Outcome results
None listed