Calcium Hydroxide vs Triple Antibiotic Paste: Which is better for treating Tooth Root Infections : A Randomized Controlled Trial

Clinical and Radiographic Assessment of Apical Periodontitis with Calcium Hydroxide vs Triple Antibiotic Paste Both when used along with Chlorhexidine Digluconate as Vehicle : A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/081404

Enrollment

Registered

2025-02-27

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K049- Other and unspecified diseases ofpulp and periapical tissues

Interventions

Intervention1: Triple Antibiotic Paste as an interventional agent Triple antibiotic paste is applied for 2 weeks then will change the dressing again for next 2 weeks. Triple antibiotic paste is a comb

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult Patients aged between 18 and 45 years. 2. Single-rooted teeth (anterior and posterior). 3. Teeth with Apical periodontitis. 4. Teeth with necrotic pulp that gave a negative response to vitality testing.

Exclusion criteria

Exclusion criteria: 1. Non-restorable teeth. 2. Teeth requiring retreatment. 3. Teeth with calcified canals. 4. 5. Teeth with internal/external root resorption. Patients with serious medical illness. 6. Patients with known allergies to the materials used in the study.

Design outcomes

Primary

Measure	Time frame
The primary objective will focus on periapical healingTimepoint: at the interval of 1 month, 3 months and 6 months	—

Secondary

Measure	Time frame
Postoperative pain will be assessed as a secondary outcome.Timepoint: Pain will be evaluated at interval of 1 week, 2 weeks and 1 month	—

Countries

India

Contacts

Public ContactDr Vijay Kumar

Deaprtment of Conservative Dentistry and Endodontics Himachal Dental College Sundernagar

drvk9900@rediffmail.com7650000300

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026