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A prospective study comparing the efficacy and outcome of intraoperative periarticular cocktail infiltration with two different adjuvants in patients undergoing total knee arthroplasty

A Prospective Randomised Double Blinded Study to compare the efficacy and outcome of intraoperative periarticular cocktail infiltration with Clonidine Vs Magnesium Sulphate and Sodium Bicarbonate in patients undergoing total knee arthroplasty - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/081384
Enrollment
66
Registered
2025-02-27
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee

Interventions

Intervention1: Magnesium Sulphate Sodium Bicarbonate: Magnesium Sulphate-50%-2ml, intraoperative periarticular infiltration Sodium Bicarbonate-8.4%,25ml,intraoperative periarticular infiltration Co

Sponsors

AIIMS Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Unilateral Total Knee Replacement

Exclusion criteria

Exclusion criteria: History of allergy to the medications used in the study,Patients undergoing extensive soft tissue release, Severe varus knees (HKA greater than 10), Inflammatory arthritis, Painful Hip pathology, Patients with intra-operative fractures, Previous history of steroid injection into the knee joint ,Patients undergoing revision surgery or any history of prior operation around the knee

Design outcomes

Primary

MeasureTime frame
To compare the post operative functional outcome in terms of pain relief and early mobilization of Clonidine as an adjuvant versus MgSO4 & NaHCO3 as an adjuvant in periarticular cocktail infiltration.Timepoint: VAS score at 2hours, 4 hours,6hours, 8 hours, 10hours, 12 hours,24 hours, 48 hours—

Secondary

MeasureTime frame
Use of rescue analgesia in the form of Injection Tramadol (50 mg), intravenous and also the frequency of the requirement of rescue analgesia during the early post operative period(i.e. within POD 5), To assess ROM post operatively till the day of discharge(POD-5)Timepoint: ROM at POD-0,1,2,3,4,5—

Countries

India

Contacts

Public ContactDr Sudeep Kumar

All India Institute of Medical Sciences, Patna

drsudeepk@aiimspatna.org9472232758

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026