Health Condition 1: B998- Other infectious disease
Conditions
Interventions
Intervention1: Inj Noradrenaline from 0 to 3 hours: Patients of sepsis with hypotension will be started on fluid therapy at 30 millilitre per kilogram as fluid bolus, fluid response will be assessed a
Sponsors
AIIMS PATNA
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients above 18 years of age 2.All patients with hypotension determined by mean arterial pressure lower than 65 mm Hg and infection as the suspected cause if they met diagnostic criteria for sepsis according to surviving sepsis guidelines more than or equal to 2 of SIRS criteria
Exclusion criteria
Exclusion criteria: 1. All those patients who already received vasopressors from outside 2. Patients in whom other causes of shock are found eventually in the course of study 3. Patients requiring vasopressors other than noradrenaline 4. Pregnant females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study shock control rate in terms of achievement of sustained MAP greater than 65 mm Hg, urine output of greater than 0.5 ml/kg/h for 2 consecutive hours, or decrease in serum lactate by more than 10% from the initial lactate level in patients of sepsis with hypotension by 6 hours of presentation to emergency department.Timepoint: 6 hours of presentation to emergency department. | — |
Secondary
| Measure | Time frame |
|---|---|
| To estimate duration of hospital stay, duration of ICU stay, and in-hospital mortality in patients of sepsis with hypotension receiving noradrenaline within 3 hrs and 3 to 6 hrs of emergency medicine department presentation. Timepoint: 28 days;To estimate number of patients requiring mechanical ventilator support and number of patients requiring renal replacement therapy among patients of sepsis with hypotension receiving noradrenaline within 3 hrs and 3 to 6 hrs of emergency medicine department presentation.Timepoint: 28 days | — |
Countries
India
Contacts
Public ContactAparna Ramjan
AIIMS PATNA
Outcome results
None listed