FindTrial
Sign In

Vocal Cord mobility recovery in previously fixed cords in laryngopharyngeal cancer after chemoradiation in 118 patients: A Hospital Based study

Assessment of Vocal Cord Mobility in Laryngopharyngeal Cancers with Fixed Vocal Cord After Definitive Chemoradiation A Prospective Hospital Based Observational Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/02/081229
Enrollment
118
Registered
2025-02-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C13- Malignant neoplasm of hypopharynx

Interventions

Intervention1: DEFINITIVE CHEMORADIATION: COMBINATION OF RADIATION THERAPY AND CHEMOTHERAPY ADMINISTERED TO PATIENT WITH LARYNGOPHARYNGEAL CANCERS WITH FIXED VOCAL CORDS Intervention2: NIL: NUL Contro

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Histologically proven laryngopharyngeal cancers with unilateral or bilateral fixed vocal cords confirmed with endoscopy or laryngoscopy, patients giving written informed consent to participate in the study,patients with ECOG PS 0 to 2,baseline CBC, LFT and RFT are within normal limits, at least 3 months of follow up after completion of treatment

Exclusion criteria

Exclusion criteria: Patients with vocal cord mobility impairment due to causes other than laryngopharyngeal cancers and its treatment (eg: congenital anomalies, trauma, neurological disorders), patients with laryngopharyngeal cancers with extra laryngeal extension or cartilage erosion,patient unwilling or unable to participate in follow-up assessments,patients with other concurrent head and neck cancers,patients with uncontrolled cardiovascular, pulmonary or metabolic renal disease,patient with metastatic laryngopharyngeal cancers with fixed vocal cords.

Design outcomes

Primary

MeasureTime frame
RESTORATION OF VOCAL CORD MOBILITY AFTER DEFINITIVE CHEMO RADIATION IN LARYNGOPHARYNGEAL CANCERS WITH PREVIOUSLY FIXED VOCAL CORDS ASSESSED USING DIRECT LARYNGOSCOPY OR ENDOSCOPY AT SPECIFIC TIME INTERVALS. COMPLETE ABDUCTION OF VOCAL CORDS DEFINED AS SEPARATION OF ATLEAST 1 CM FROM MIDLINE WILL BE CONSIDERED AS INDICATOR RESTORED MOBILITY.Timepoint: At 6 weeks post definitive chemoradiation and at 3 months post definitive chemoradiation—

Secondary

MeasureTime frame
To assess for acute radiotherapy induced toxicities,to assess the voice related quality of life using Voice Handicap Index (VHI) in these group of patients. Timepoint: Acute Radiotherapy Induced toxicities will be assessed during treatment weekly. Voice Related Quality of life will be evaluated using Voice Handicap Index pre treatment, at 6 weeks post treatment and at 3 months post treatment—

Countries

India

Contacts

Public ContactDr Anupama Das

Dr Bhubaneswar Borooah Cancer Institute

anupamadas56@gmail.com8729994867

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026