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Evaluation of proteolytic enzymes in managing postendodontic pain

Comparative evaluation of effect of two different proteolytic enzyme on severity of post-operative pain after a single visit endodontic treatment assessed over three days randomized control trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/081221
Enrollment
39
Registered
2025-02-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K040- Pulpitis

Interventions

Intervention1: Trypsin chymotrypsin complex: chymorol forte type of proteolytic enzyme, 5 mg thrice a day given for 3 days Intervention2: Serratiopeptidase: Type of proteolytic enzyme,10 mg thrice a d

Sponsors

Dr darshan turkhade
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: mandibular first molar teeth and showing no radiographic evidence of periapical or periodontal pathosis. healthy crown structure and good prognosis.

Exclusion criteria

Exclusion criteria: pregnant females. teeth with bad prognosis. patients who have taken analgesics 24 hrs prior to treatment.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare effect of two different proteolytic enzyme on severity of post-operative pain after a single visit endodontic treatment assessed over three days.Timepoint: 3 days—

Countries

India

Contacts

Public ContactDr Rajiv Khode

Dr Hedgewar Dental College & Hospital

rajiv.khode@gmail.com8208899410

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026