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comparing two types of anesthesia for brain surgery: one without opioids and one with opioids. We want to see which keeps blood pressure stable during surgery and leads to better overall results. This helps improve safety and comfort for patients having brain surgery.

To compare opioid free and opioid based anaesthesia techniques for intraoperative hemodynamic stability and overall outcome in patients undergoing supratentorial craniotomy - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/081182
Enrollment
76
Registered
2025-02-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S048- Injury of other cranial nerves

Interventions

Intervention1: Opioid free anaesthesia : To compare the intraoperative hemodynamic stability and postoperative complications, by the use of INJECTION DEXMEDETOMIDINE (GROUP D which is my non opioid g

Sponsors

King george medical university Department of Anaesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient in the age group of 18 to 60 years of either gender Patient undergoing craniotomy and excision of Supratentorial tumor ASA physical status I and III Glasgow Coma Scale (GCS) 15

Exclusion criteria

Exclusion criteria: Patient Refusal Psychiatric Disease Previous Cranial Surgery Allergy to Study Drugs Pregnancy and Lactation Opioid Abuse

Design outcomes

Primary

MeasureTime frame
Comparison of mean arterial pressure at different time points between the two group.Timepoint: before induction, after induction and at the time of induction, 15 minute to end of surgery and before extubation and after extubation—

Secondary

MeasureTime frame
Comparison of the following parameters between two groups. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure(DBP), Pain score (NRS), Depth of anaesthesia (BIS), Intraoperative brain relaxation score- Post operative nausea & vomiting (PONV) Postoperative respiratory depression Patient satisfaction score Time to emergence from general anaesthesia Patient outcome using extended Glasgow outcome scale (E-GOS) at the time of discharge from the hospital. Timepoint: 24hrs to 48hrs—

Countries

India

Contacts

Public ContactProf Monica Kohli

King Georges Medical University Lucknow

monica_kohli@rediffmail.com9839041228

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026