Health Condition 1: M179- Osteoarthritis of knee, unspecified
Conditions
Interventions
Intervention1: Anthropometric, biomechanical and finite element analysis of knee joint: The patients will be selected using eligibility criteria and will be divided into two groups: the intervention/s
Sponsors
All India Institute of Medical Sciences AIIMS Rajkot
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 35 years and above. 2. Patient with degenerative changes in knee with any deviation from the normal mechanical axis.
Exclusion criteria
Exclusion criteria: 1. Patients under 35 years. 2. Patients with any contraindication for MRI like electronic device, metallic implants, etc. 3. Patients with claustrophobia. 4. Neurological disorders, systemic disorders, muscular dystrophy, metabolic bone diseases affecting bone metabolism. 5. Soft tissue, or bone swelling causing knee misalignment. 6. Axial skeleton deformities. 7. Conditions requiring surgery. 8. Already operated cases for knee joint osteoarthritis. 9. Gross deformity in proximal (hip) and distal (ankle joint and foot) segments. 10. BMI above morbid obesity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The patients will be selected using eligibility criteria and provide written consent. Demographics and medical history will be recorded via a patient information sheet. They will be divided into two groups: the study group, receiving customized orthotics after correction of the knee joint mechanical axis, and the control group, receiving conventional management (e.g., physiotherapy, knee belt). Both groups will be followed up at 3-month intervals. At baselines: A.MRI will be done of the knee joint affected side. B. Anthropometric analysis of knee joint variables will be conducted as follows using RadiANT DICOM Viewer software: C. Knee joint biomechanical findings (Range of motion) 1.Flexion at knee joint (Active/passive) 2.Extension at knee joint (Active/passive) 3.Internal rotation (active/passive) 4.External rotation (active/passive) Timepoint: Both groups will be followed up at 3-month intervals. MRI will be performed at the baseline and will be done at 9 and 18 months, whereas arthro-kinematic analysis shall be done at 3, 6, 9, 12, 15 and 18 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Finite element analysis of the knee joint (side) will be done using the sift copies of the MRI scans using the following parameters: 1 Contact area (mm3) 2 Contact pressure (MPa) Mean/Peak 3 Pore pressure (MPa) Mean/Peak 4 Tensile stress% (Mean/Peak) 5 Tensile strain% (Mean/Peak) 6 Translation of medial femoral condyle(mm) 7 Translation of lateral femoral condyle (mm) 8 Mechanical axis of hip joint 9 Femoro-tibial (Knee joint) mechanical axis 10 Medial collateral ligaments 11 Lateral collateral ligaments Timepoint: Both groups will be followed up at 3-month intervals. MRI will be performed at the baseline and will be done at 9 and 18 months, whereas arthro-kinematic analysis shall be done at 3, 6, 9, 12, 15 and 18 months. Finite element analysis will be done at baseline, 9 months and 18 months stage in the follow up. | — |
Countries
India
Contacts
Public ContactDr Sundip Charmode
All-India Institute of Medical Sciences Rajkot
Outcome results
None listed