Comparing pathological complete response rate after Short Course Radiochemotherapy vs. Long Course Chemoradiotherapy Before Surgery in Locally Advanced Rectal Cancer patients.

A PROSPECTIVE RANDOMISED STUDY TO COMPARE SEQUENTIAL SHORT COURSE RADIOCHEMOTHERAPY VERSUS CONCURRENT LONG COURSE CHEMORADIOTHERAPY BEFORE TOTAL MESORECTAL EXCISION IN LOCALLY ADVANCED RECTAL CANCER. - NIL

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/081061

Enrollment

Registered

2025-02-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C20- Malignant neoplasm of rectum

Interventions

Intervention1: Sequential short course radiochemotherapy before total mesorectal excision in locally advanced rectal cancer.: Total neoadjuvant therapy includes neoadjuvant short course radiotherapy (

Eligibility

Inclusion criteria

Inclusion criteria: 1. ECOG 0-1 2. Biopsy proven case of locally advanced rectal adenocarcinoma 3. Pelvic MRI has atleast one the following features: (i)Clinical tumour stage cT3, cT4a or cT4b (ii)Nodal stage cN1, cN2 (iii)Involvement of mesorectal fascia

Exclusion criteria

Exclusion criteria: 1.Metastatic disease 2.Recurrent rectal cancer 3.Uncontrolled medical comorbidities

Design outcomes

Primary

Measure	Time frame
1.To compare the local disease control rate with these two treatments. 2.To compare the pathological complete response rate in two treatment groups. Timepoint: At completion of treatment and at 3 months after treatment.	—

Secondary

Measure	Time frame
To compare the acute and chronic toxicities with these two treatment arms.Timepoint: During treatment and at 3 months after treatment.	—

Countries

India

Contacts

Public ContactDR AJAY KUMAR BANSAL

Post graduate institute of medical education and research chandigarh

drkapoor.r@gmail.com9872648344

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026