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Comparing 2 drugs for preventing spinal anaesthesia induced shivering in leg and lower abdominal surgeries

Comparison of Effectiveness of Norepinephrine versus Phenylephrine Infusions in Preventing Post-Spinal Anaesthetic Shivering in Lower Limb and Lower Abdominal Surgeries: A Randomised Controlled Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080993
Enrollment
168
Registered
2025-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M849- Disorder of continuity of bone, unspecified Health Condition 2: K409- Unilateral inguinal hernia, without obstruction or gangrene Health Condition 3: N211- Calculus in urethra Health Condition 4: O- Medical and Surgical

Interventions

Intervention1: Norepinephrine: Norepinephrine infusion (5 mics/ml) will be administered for 1 group Intervention2: Phenylephrine: Phenylephrine infusion (50mics/ml) will be administered for 2nd group

Sponsors

S. Suryanarayanan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients within the age group of 18 to 55 years posted for orthopaedic surgeries of lower limb or hip and lower abdominal surgeries belonging to ASA-PS category 1 or 2

Exclusion criteria

Exclusion criteria: Refusal to consent Patient with any contraindication for spinal anaesthesia Allergy to Phenylephrine or Norepinephrine Those patients requiring additional sedation or analgesia or general anaesthesia either due to inadequate sensory or motor block or due to unanticipated prolongation of the surgery. Patients requiring blood transfusion Postoperative Visual Analogue Score more than 5 In any patient to whom preoperative anxiolytic medication is not administered Obesity (BMI more than 35kg/m2) Those suffering from severe vital organ dysfunction (such as heart, brain, liver and kidney). Fever (axillary temperature more than 37 degree celcius)

Design outcomes

Primary

MeasureTime frame
To determine the incidence of post spinal anesthetic shivering.Timepoint: 2, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120 and 180 minutes—

Secondary

MeasureTime frame
To determine the severity of shivering using Bedside Shivering Assessment Score.Timepoint: 2, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120 and 180 minutes;To evaluate the hemodynamic changes with study drugsTimepoint: 2, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120 and 180 minutes—

Countries

India

Contacts

Public ContactSURYANARAYANAN S

Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research

surya19692@gmail.com8754924600

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026