Health Condition 1: B999- Unspecified infectious disease Health Condition 2: E46- Unspecified protein-calorie malnutrition Health Condition 3: G969- Disorder of central nervous system, unspecified Health Condition 4: J22- Unspecified acute lower respiratory infection Health Condition 5: K929- Disease of digestive system, unspecified Health Condition 6: Q209- Congenital malformation of cardiacchambers and connections, unspecified Health Condition 7: N29- Other disorders of kidney and ureter in di
Conditions
Interventions
Intervention1: Plasmalyte A: At the time of enrolment, baseline data will be recorded in a proforma. This will
include name, gender, diagnosis, any significant history, previous hospitalization,
dis
Sponsors
Jawaharlal Nehru Medical College
Eligibility
Inclusion criteria
Inclusion criteria: 1. Admitted to PICU or emergency due to medical conditions. 2. Need for intravenous fluid administration 3. Serum sodium more than 130 mmol/L (measured on admission or no longer than 48 h before randomization)
Exclusion criteria
Exclusion criteria: 1. Pre-existing conditions like cardiac conditions and chronic kidney disease. 2. Disease-specific IVF protocols - Traumatic brain injury or at risk of cerebral edema, Burns, Post-liver transplant, post-renal transplant, Diabetic ketoacidosis, Oncology patients needing hyperhydration. 3. Blood sugar less than 60 mg/dl at the time of start of intervention and during 48 hours of intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in serum chloride by at least 5 mmol/LTimepoint: At baseline and at the end of 48 hours from the beginning of the infusion of intervention/comparator agents | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. New-onset acute kidney injury (AKI). 2. Length of PICU stay 3. Length of hospital stay. 4. PICU-free survival. Timepoint: New onset AKI within 48 hours of beginning of intervention/comparator agents | — |
Countries
India
Contacts
Public ContactArshad P
Jawaharlal Nehru Medical College
Outcome results
None listed