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To check effect of two different drugs i.e. eperisone hydrochloride vs chlorzoxazone to releive muscle pain in head and neck region.

To evaluate efficacy and safety of eperisone hydrochloride vs chlorzoxazone in patients with myofascial pain dysfunction syndrome :A randomized controlled double Blinded open labelled trial - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080968
Enrollment
28
Registered
2025-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M624- Contracture of muscle

Interventions

Intervention1: Eperisone Hydrochloride: Tablet Eperisone hydrochloride (50mg) to be given per day twice for 7days Control Intervention1: Chlorzoxazone: Chlorzoxazone Tablet (250mg) for twice a day for

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients attending outpatient department both male and female between 20 to 55 yrs. 2.Presence of unilateral pain, muscle tenderness, Clicking or popping noise in the TMJ, Limitation of jaw movement. 3.No radiographic evidence of bony pathology. 4.No tenderness in TMJ area on palpation via the external auditory meatus. 5.Willing to take medications as directed and come for follow up were included.

Exclusion criteria

Exclusion criteria: 1.Bilaterally Edentulous arches 2.Pregnant or lactating women 3.Patient with known H/O hypersensitivity to any of the trial drugs 4.Medical disease like suffering from hematologic /endocrine/impaired liver function/kidney disorder. 5.Unwilling to be a part of study

Design outcomes

Primary

MeasureTime frame
1.Benefit in improvement of pain intensity 2.Benefit in duration of pain reduction 3.Improvemet in mouth opening.Timepoint: At baseline,3rd day,5th day,7th day.

Secondary

MeasureTime frame
Incidence of any adverse EffectsTimepoint: At baseline,7 days

Countries

India

Contacts

Public ContactDr Pranali Mohan Mane

D Y Patil School Of Dentistry , Nerul ,Navi Mumbai

mandavi.waghmare@dypatil.edu08108069665

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026