Comparing the effects of two anesthesia drugs, etomidate and propofol, on blood pressure during induction for General anaesthesia in patients undergoing liver transplant surgery

Effect of etomidate versus propofol on hemodynamic parameters for induction in recipients undergoing liver transplant surgery: a randomized control trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080802

Enrollment

Registered

2025-02-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Etomidate: Etomidate as induction agent Dose: 0.2 to 0.3 mg per kg Frequency: Once Route: intravenous Duration: once Control Intervention1: Propofol: Propofol as induction agent Dose: 2

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 to 60 years Patients undergoing Liver Transplant Recipient Surgery

Exclusion criteria

Exclusion criteria: Patients who do not consent for the study. Recipients for Acute liver failure and acute on chronic liver failure Patients with preexisting cardiac disease Patients with Cirrhotic Cardiomyopathy Patients having allergy to propofol or etomidate

Design outcomes

Primary

Measure	Time frame
To study change in mean arterial pressure during induction every minute till 10 minutes.Timepoint: 10 minutes	—

Secondary

Measure	Time frame
To compare hemodynamic parameters: HR-heart rate, SBP- systolic blood pressure, DBP- Diastolic blood pressure, CO- cardiac output, SV- stroke volume, SVV- Stroke volume variation during induction every minute till 10 minutes. Timepoint: 10 minutes after induction;To compare use of vasopressor during induction every minute till 10 minutes. Timepoint: 10 minutes after induction;To compare rate of complication like myoclonus and pain on injection during induction every minute till 10 minutes.Timepoint: 10 minutes after induction	—

Measure

Time frame

To compare hemodynamic parameters: HR-heart rate, SBP- systolic blood pressure, DBP- Diastolic blood pressure, CO- cardiac output, SV- stroke volume, SVV- Stroke volume variation during induction every minute till 10 minutes. Timepoint: 10 minutes after induction;To compare use of vasopressor during induction every minute till 10 minutes. Timepoint: 10 minutes after induction;To compare rate of complication like myoclonus and pain on injection during induction every minute till 10 minutes.Timepoint: 10 minutes after induction

—

Countries

India

Contacts

Public ContactDr Anil Yadav

Institute Of Liver and Biliary Sciences

doc.anilyadav@gmail.com8089337600

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026