Comparative assessment of dexmedetomidine (analgesic and sedative drug) as a contributory agent to 2 percent plain lignocaine and 2 percent lignocaine with 1:200,000 adrenaline (drug to increase anesthesia time) as local anesthetic agents for removal of impacted lower 3rd molar

Comparative evaluation of Dexmedetomidine as an adjuvant to 2 percent plain lignocaine and 2 percent lignocaine with 1:200,000 adrenaline as local anesthetic agents for surgical removal of impacted mandibular third molars - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080772

Enrollment

Registered

2025-02-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Dexmedetomidine WITH 2% plain lignocaine: Dexmedetomidine is a selective alpha 2 agonist used in anesthesia. When used with lignocaine it can enhance analgesia, prolong duration of acti

Eligibility

Inclusion criteria

Inclusion criteria: patients with ASA 1 status patients with presence of impacted lower 3rd molar indicated for extraction.

Exclusion criteria

Exclusion criteria: -Participants with a history of drug abuse and alcohol intoxication -Patients with Immunocompromised status. -Patients with comorbidities such as hypertension and diabetes -Presence of any local infection, -Women on oral contraceptives or pregnant and nursing mothers -Patients allergic to the LA used in the study

Design outcomes

Primary

Measure	Time frame
onset and duration of LA, hemodynamic stability by recording pulse rate, blood pressure and spo2 at different intervals of time and anti-inflammatory action by measuring mouth opening and facial swelling at 24-48-hour, 48-72-hour, and 1-week follow-up periodTimepoint: baseline- pre operative, postoperative - 24hrs- 48 hrs post operative -48hrs to 72 hrs post operative- 1 week	—

Secondary

Measure	Time frame
mouth opening/ VAS score after 3 days post operativeTimepoint: 3 days post operative	—

Countries

India

Contacts

Public ContactKanishka Tyagi

subharti dental college and hospital

tyagikanishka10@gmail.com09456553100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026