Health Condition 1: F112- Opioid dependence
Conditions
Interventions
Intervention1: Opioid Based (Group A):: Opioid anesthesia- propofol (1-2 mg/kg), fentanyl (1-2 g/kg), and atracurium (0.5 mg/kg) will be administered from pre-surgery to the end of surgery.
Control
Sponsors
Dr Puneet Khanna
Eligibility
Inclusion criteria
Inclusion criteria: 1.)Age above 60 years. 2.) Undergoing major surgery over 60 minutes. 3.) Can give informed consent themselves. 4.) Minimum cognitive performance required to participate is ACE-III score more than 88.
Exclusion criteria
Exclusion criteria: 1.) Patients with a history suggestive of dementia (either listed in the medical record or reported by the patient) or any neurological disorder 2.) History of alcohol abuse, chronic opioid or other substance abuse. 3.) History of any cerebral surgeries, stroke. 4.) History suggestive of psychiatric disease like schizophrenia, dementia, anxiety or other disorder affecting cognition, mental dysfunction. 5.) Prescription of central nervous system – active medications (e.g.: antidepressants antipsychotics, sedatives).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.The association between NIRS and the incidence of POCD in patients. 2.Measurement of cerebral hypoperfusion between opioid and opioid-sparing anesthesia groups. Timepoint: 1.) Postoperative delirium- Immediately post operatively and 24 hours post operatively. 2.) Post operative cognitive dysfunction- 24 and 48 hours post operatively, at 30 days post operatively. 3.)Cerebral Oxygenation- 10 minutes intra operatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of POCD between opioid and opioid-sparing anesthesia groups.Timepoint: 24 hrs Post-operative(ACE-III) | — |
Countries
India
Contacts
Public ContactDr Puneet Khanna
All India Institute of Medical Science (AIIMS), New Delhi.
Outcome results
None listed