Health Condition 1: A91- Dengue hemorrhagic fever
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
Dr Chandrasekar M
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients diagnosis with dengue fever, Dengue Hemorrhagic Fever or Dengue Sock Syndrome as per WHO criteria 2. Patients who are hospitalized for dengue management in the tertiary care hospital. 3. Patients aged 18 years and above. 4. Patients who have received one platelet transfusion. 5. Patients or their legal guardians, who provide written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Other Infections like malaria, typhoid that could affect hematological parameters done by Fever profile. 2. Patients with pre-existing chronic hematological disorders (e.g., leukemia, aplastic anemia) that confound results. 3. Below 18 years old age individuals due to the distinct physiological differences between children and adults. 4. Patients on immunosuppressive therapy or chemotherapy, as these treatments can affect leukocyte counts and platelet indices. 5. Pregnant women, due to the physiological changes in hematological parameters during pregnancy. 6. Patients with severe chronic diseases (e.g., end-stage renal disease, severe liver cirrhosis) that could impact hematological parameters and recovery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study is to evaluate the changes in platelet indices (Platelet Count [PC], Mean Platelet Volume [MPV], Platelet Distribution Width [PDW], Plateletcrit [PCT], and Platelet-Large Cell Ratio [P-LCR]) before and after platelet transfusion in hospitalized dengue patients.Timepoint: 1 Year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Analyzing changes in leukocyte count and platelet-to-WBC ratio (PWR) pre- and post-transfusion and their association with recovery outcomes. 2. Identifying morphological changes in white blood cells (e.g., hypersegmented neutrophils, reactive lymphocytes, toxic granules) as potential predictors of hematological response and complications following platelet transfusion. 3. Comparing the efficacy of manual and automated methods in assessing platelet and leukocyte parameters, including morphological changes. 4. Investigating the relationship between PWR changes and recovery speed or hospital stay duration. Timepoint: 1 Year | — |
Countries
India
Contacts
Public ContactDr Chandrasekar M
Galgotias University, Greater Noida, Uttar Pradesh
Outcome results
None listed