To compare if pressure required to keep lung units open which is set using EIT is not inferior to the standard method

A Non Inferiority Trial of EIT Guided PEEP Optimization Versus ARDSnet Low PEEP Protocol in ARDS Patients OPT PEEP trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080692

Enrollment

Registered

2025-02-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J189- Pneumonia, unspecified organism

Interventions

Intervention1: Electric Impedance Tomography guided PEEP titration: EIT is a non invasive method for assessing lung for ventilation Control Intervention1: ARDSnet low PEEP table: ARDSnet low PEEP tabl

Eligibility

Inclusion criteria

Inclusion criteria: Patients age above 18 years Diagnosed with ARDS according to the Berlin Definition Intubated and mechanically ventilated

Exclusion criteria

Exclusion criteria: Pregnancy EIT contraindications example pacemaker or automatic implantable cardioverter defibrillator Severe intracranial hypertension Pneumothorax pneumomediastinum subcutaneous emphysema or high risk of pneumothorax Refractory hypotension as assessed by attending physician End stage lung disease

Design outcomes

Primary

Measure	Time frame
PaO2 and FiO2 ratioTimepoint: 0 6 12 18 24 hours	—

Secondary

Measure	Time frame
Driving pressure Mechanical powerTimepoint: 0 6 12 18 24 hours	—

Countries

India

Contacts

Public ContactDr Anant Vikram Pachisia

Medanta The Medicity

rggoyat@gmail.com8901000102

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026