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To compare spinal administration of drug morphine versus fentanyl for pain relief during and after surgery in patients undergoing surgeries of liver or gall bladder.

To compare the efficacy and safety of intrathecal Morphine and Fentanyl on intra-operative and post-operative analgesia in patients undergoing hepatobiliary surgeries under general anaesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080666
Enrollment
60
Registered
2025-02-17
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K70-K77- Diseases of liver Health Condition 2: K80-K87- Disorders of gallbladder, biliary tract and pancreas

Interventions

Intervention1: Intrathecal 0.25mg of morphine in patients undergoing hepatobiliary surgeries under general anaesthesia: 1 ml of 0.25mg morphine diluted to 2 ml will be administered intrathecally for i

Sponsors

Bangalore Medical College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients belonging to American Society of Anaesthesiologist class I-II, willing to give informed written consent, scheduled to undergo elective hepatobiliary surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients not willing to give consent Patients undergoing emergency surgeries Patients having allergy to study drugs Patients having spinal anomalies or infection, coagulopathy, increased intracranial pressure Patients belonging to American Society of Anaesthesiologists class III-V Expected duration of surgery less than 90 min

Design outcomes

Primary

MeasureTime frame
To measure and compare the two groups based on requirement of intra-operative and post-operative rescue analgesics Timepoint: To measure and compare the two groups based on requirement of intra-operative and post-operative rescue analgesics at 2nd, 4th, 8th, 12th and 24th hour following surgery.—

Secondary

MeasureTime frame
To assess post-operative analgesia using VAS scoreTimepoint: To assess the VAS score at 2,4,8,12 and 24 hours post-operatively;To compare the incidence of side effects such as hypotension, nausea, vomiting, pruritus, cough, respiratory depression and sedationTimepoint: To assess the incidence of side effects and their severity based on four point ordinance scale upto 24 hours post-operatively—

Countries

India

Contacts

Public ContactDr Malavika P Nair

Bangalore Medical College and Research Institute

pnairmalavika@gmail.com9746900270

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026