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Effect of 3% Saline on optic nerve sheath size and its correlation with blood flow in the brain in patients with moderate to severe head injury

3% Hypertonic saline induced changes in Optic Nerve Sheath Diameter (ONSD) and its correlation with Transcranial colour coded Duplex (TCCD) parameters in patients with moderate to severe Traumatic Brain Injury (TBI): A prospective observational study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/02/080638
Enrollment
85
Registered
2025-02-17
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S062- Diffuse traumatic brain injury

Interventions

Intervention1: NIL: NIL

Sponsors

All India institute of medical sciences Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patient aged 18yrs and above 2.admitted in ICU 3.Diagnosed with Moderate/severe TBI requiring hypertonic saline therapy

Exclusion criteria

Exclusion criteria: 1.patient refusal 2.preexisting optic nerve disorders 3.spontaneous intracranial haemorrhage,stroke 4.skull fractures 5.hemodynamic instability 6.brain stem death

Design outcomes

Primary

MeasureTime frame
To assess the correlation between change in ONSD and change in TCCD parameters following 3% hypertonic saline therapy in patients with moderate to severe traumatic brain injury TBI.Timepoint: Baseline,10mins and 1hr after hypertonic saline administration from ICU admission till day 5 of ICU or continuation of hypertonic saline therapy whichever is earlier—

Secondary

MeasureTime frame
1.To assess the correlation between changes in TCCD parameters and clinical improvement [change in Glasgow Coma Scale (GCS)] in patients with moderate to severe TBI following 3% hypertonic saline therapy. 2.To assess the correlation between changes in ONSD and clinical improvement (change in GCS) in patients with moderate to severe TBI following 3% hypertonic saline therapy. 3.To assess the effects of 3% hypertonic saline administration on electrolyte disturbances and hemodynamic parameters in patients with TBI. 4.To evaluate clinical outcomes including length of ICU stay, length of ventilatory stay, incidence of AKI, total hospital length of stay, and mortality ratesTimepoint: 1.GCS,serum electrolytes and hemodynamic parameters during ICU admission and till day 5 of ICU. 2.clinical outcomes will be noted till hospital stay or till the date of death in hospital—

Countries

India

Contacts

Public ContactPharanitharan

All India institute of medical sciences Jodhpur

drmsadik@gmail.com9414849733

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026