A study to show the effect Of Vitamin D Supplementation On Serum Pigment epithelium deerived factor and vascular endothelial growth factor in Diabetic Retinopathy patients

Effect of vitamin D supplementation on serum levels of pigment epithelium derived factors and vascular endothelium growth factors in patients of Diabetic Retinopathy - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080622

Enrollment

120

Registered

2025-02-14

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E103- Type 1 diabetes mellitus with ophthalmic complications Health Condition 2: E113- Type 2 diabetes mellitus with ophthalmic complications

Interventions

Intervention1: Vitamin D3: 60000IU once in a week for 12 weeks Control Intervention1: Placebo: once in a week for 12 weeks

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Non Proliferative and Proliferative Diabetic Retinopathy

Exclusion criteria

Exclusion criteria: i. Patients receiving vitamin D and calcium supplements. ii. Patients taking any other medication that could change vitamin D metabolism, such as Rifampicin or Phenytoin. iii. Patients with very low vitamin D / sufficient vitamin levels iv. patients who have recieved injection antiVEGF for past 3 months v. patients who have recieved laser in retina for past 1 month

Design outcomes

Primary

Measure	Time frame
serum levels of vascular endothelial growth factor and pigment epithelial derived growth factor after vitamin D supplementationTimepoint: 12 weeks	—

Secondary

Measure	Time frame
serum levels of vascular endothelial growth factor and pigment epithelial derived growth factor in various grades of diabetic retinopathyTimepoint: 12 weeks	—

Countries

India

Contacts

Public ContactProf SIMI ZAKAURRAB

AMUIO, JNMCH, AMU, Aligarh

s_zrab@yahoo.co.in8439105927

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026