To compare the Effects of Dexmedetomidine And Esmolol on Attenuation Of Extubation Responses

Comparison of Effects of Dexmedetomidine And Esmolol on Attenuation Of Extubation Responses - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080605

Enrollment

Registered

2025-02-14

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: DEXMEDITOMIDINE: Intravenous Dexmeditomidine 0.5mcg/kg ten minutes before extubation Control Intervention1: ESMOLOL: Intravenous Esmolol 0.5 mg/kg ten minutes before extubation.

Eligibility

Inclusion criteria

Inclusion criteria: 1. BMI 20-35 kg/m2 2. ASA grade 1 to ASA grade 2 fit patients 3. Availability of written informed consent 4. Hemodynamically stable patients with all routine investigations within normal limits.

Exclusion criteria

Exclusion criteria: 1. Allergy to the study drugs. 2. Patient with pre-op Heart rate 45 beats/min or less. 3. Patient on recent oral opioids in last 3 months. 4. Pregnancy 5. Any cognitive dysfunction 6. Any psychiatric disorders 7. Patient with renal insufficiency or liver impairment. 8. Patient with coagulopathy. 9. Patient with neuropathy. 10. Patient unwilling to get enrolled in the study.

Design outcomes

Primary

Measure	Time frame
To compare efficacy between Dexmedetomidine and Esmolol in the attenuation of hemodynamic response i.e, Heart Rate and Blood Pressure, to tracheal extubation.Timepoint: Vital parameters were recorded during the following timelines T0- baseline vitals before injection of study drug T1- At the time of bolus injection of study drug T2- 1 min after injection of study drug T3- 5 mins after extubation T4- 15 mins after extubation T5- 30 min after extubation T6 – 1 hour after extubation T7- 1 and a half hour after extubation T8- 2 hour after extubation	—

Measure

Time frame

To compare efficacy between Dexmedetomidine and Esmolol in the attenuation of hemodynamic response i.e, Heart Rate and Blood Pressure, to tracheal extubation.Timepoint: Vital parameters were recorded during the following timelines T0- baseline vitals before injection of study drug T1- At the time of bolus injection of study drug T2- 1 min after injection of study drug T3- 5 mins after extubation T4- 15 mins after extubation T5- 30 min after extubation T6 – 1 hour after extubation T7- 1 and a half hour after extubation T8- 2 hour after extubation

—

Secondary

Measure	Time frame
To assess Ramsay sedation score & adverse effects if anyTimepoint: Sedation score & incidence of adverse effects was observed at T1- At the time of bolus injection of study drug T2- 1 min after injection of study drug T3- 5 mins after extubation T4- 15 mins after extubation T5- 30 min after extubation T6 - 1 hour after extubation T7- 1 & a half hour after extubation T8- 2 hour after extubation	—

Countries

India

Contacts

Public ContactDr Sheetal Jayakar

DR. D.Y.PATIL MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTRE, PIMPRI, PUNE

sheetaljayakar2@gmail.com7756850492

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026