Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
Intervention1: Real transcranial alternating current stimulation (Real tACS): Real tACS Protocol: single session of real closed-loop transcranial alternating current stimulation (tACS) intervention (2
Sponsors
Suriya Prakash Muthukrishnan
Prashant Tayade
Ratna Sharma
Simran Kaur
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of idiopathic Parkinsons disease with Hoehn and Yahr Stages II to IV while on medication, 2. MDS UPDRS III motor improvement of less than or equal to 30 per cent while on medication compared to while off medication, 3. Patients on stabilized medication.
Exclusion criteria
Exclusion criteria: 1. Dopamine dysregulation syndrome, 2. Other neurological diseases such as major depression, dementia, attention deficit disorder, psychosis, or essential tremor, 3. History of epilepsy, traumatic brain injury or brain surgery, 4. Patients on psychoactive or narcoleptic medications, 5. Patients enrolled for another drug, device, biologic, or intervention trial currently or within the preceding 90 days, 6. Patients who are pregnant, breastfeeding, or planning for pregnancy during the study duration, 7. Patients with metal implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome which will be used to determine the effects of the intervention is Movement Disorder Society Unified Parkinsons disease rating scale part III, a reliable and valid metric for objectively evaluating motor symptoms in Parkinsons disease.Timepoint: Motor symptoms in Parkinsons disease will be objectively assessed using Part III of the Movement Disorder Society Unified Parkinsons Disease Rating Scale, MDS UPDRS III at two specific time points. 1. Baseline, 30 minutes before the intervention, 2. Post intervention, 30 minutes after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Freezing of gait QuestionnaireTimepoint: Outcome measures will be recorded before and after the intervention on the same day;Timed up and go testTimepoint: Outcome measures will be recorded before and after the intervention on the same day.;Word memory taskTimepoint: Outcome measures will be recorded before and after the intervention on the same day.;Digit span forward taskTimepoint: Outcome measures will be recorded before and after the intervention on the same day. | — |
Countries
India
Contacts
Public ContactSuriya Prakash Muthukrishnan
All India Institute of Medical Sciences, Delhi
Outcome results
None listed